Clinicopathologic Importance of Women with SCC Cytology on Siriraj Liquid-Based Cervical Cytology

Cervical cytology is accepted worldwide for early detection of cervical neoplasia since the inception of the conventional Pap smear. The 2001 Bethesda Terminology System implemented the criteria for determining the squamous cell cytologic abnormalities as atypical squamous cells (ASC), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL) and squamous cell carcinoma (SCCA) (Solomon et al., 2002). The previous publications reported the rate of serious pathology and invasive lesions in women with SCCA cytology on conventional smears were 2697.9% and 15-33.3%, respectively (Massad et al., 2001; Charoenkwan et al., 2006). The study of correlation between cancer cytology on repeat Pap smear and colposcopic biopsies in 8 patients presented the rate of cancer as 38%. Benign or cervical intraepithelial neoplasia (CIN) 2-3 pathologies were detected in 13% and 51% of patients, respectively (Massad et al., 2001). A retrospective study in 48 patients with SCCA abnormality